![]() ![]() Knowledge about the substrates, inducers, and inhibitors of CYP isoforms, as well as the polymorphisms of CYP enzymes may be used as an aid by clinicians to determine therapeutic strategy, and treatment doses for drugs that are metabolized by CYP gene products. The present review is a comprehensive compilation of cytochrome P450 structure, function, pharmacogenetics, pharmacoepigenetics and clinical significance. Genetic polymorphisms and epigenetic changes in CYP genes may be responsible for inter-individual and interethnic variations in disease susceptibility and the therapeutic efficacy of drugs. Predictions based on in silico analyses followed by validation have identified several microRNAs that regulate CYPs. Many chemotherapeutic drugs can cause drug interactions due to their ability to either inhibit or induce the CYP enzyme system. ![]() CYP enzyme inhibition is a principal mechanism for metabolism- based drug-drug interactions. She studied at TN government school till grade seven she couldn't continue her studies as she became busy. She has 7 siblings, one sister and six brothers. Her father was a choreographer in Tamil movies and her mother was a professional dancer. CYP enzymes can be transcriptionally activated by various xenobiotics and endogenous substrates through receptor-dependent mechanisms. Nalini was born 28 August 1984 as second among eight children to Moorthi and Prema at Tamil Nadu. ![]() Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions. The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
March 2023
Categories |